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doi: 10.3390/cells8030204 232

In addition, endosomal acidification is necessary for the priming of endo-lysosomal proteases to facilitate viral fusion through TMPRSS2 [20]

APOE, Apolipoprotein E

When levels are low, your cells become more vulnerable to oxidative stressa state where there are too many reactive molecules (free radicals) and not enough antioxidants to neutralize them